Lepic is a surname of French origin. Notable people by that name include:
Ludovic-Napoléon Lepic (1839–1889), French artist, archaeologist and patron of the arts. Ermin Lepić, (known as Lepa) is a Bosnian volleyball player. Louis Lepic (1765-1827), French cavalry commander of the French Revolutionary and Napoleonic Wars. Hugues Lepic (born 1965), private equity professional and investor.