Khoza is a surname. Notable people with the surname include:
Buti Khoza (born 1988), South African footballer Irvin Khoza (born 1948), South African football administrator and businessman Makhosi Khoza (born ?), South African politician and writing system creator Malibongwe Khoza (born 2004), South African soccer player Muzi Khoza, South African politician Nonhlanhla Khoza (born ?), South African politician Ntshingwayo Khoza (1809–1883), Zulu general Snowy Khoza (born ?), South African business executive