The Brazilian Controlled Drugs and Substances Act (), officially Portaria nº 344/1998, is Brazil's federal drug control statute, issued by the Ministry of Health through its National Health Surveillance Agency (Anvisa). The act also serves as the implementing legislation for the Single Convention on Narcotic Drugs, the Convention on Psychotropic Substances, and the United Nations Convention Against Illicit Traffic in Narcotic Drugs and Psychotropic Substances in the country.
The list was last updated in May 2024.
Terminology:
Prescription notification - a standardized document intended for notifying Anvisa of the prescription of medications. Written by the doctor and retained by the drugstore Prescription - a written medication order that provides usage instructions for the patient. Special control prescription - a prescription that is filled out in two copies, one that is retained by the drugstore, and another stays with the patient for usage guidance. It can be provided in a digital signed form.
Overview +Controlled goods classes Class Type of substanceRx type A1 Narcotic drugs: analgesics, opioids, non-opioids, other analgesics Yellow "A" Prescription Notification form (provided by Anvisa), along with a prescription. A2 Narcotic drugs: analgesics, opioids and non-opioids A3 Psychoactive drugs: central nervous system stimulants B1 Psychoactive drugs: antiepileptics, sleep inducers, anxiolytics, antidepressants, tranquilizersBlue "B" Prescription Notification form (the doctor request a printing press for it) B2 Psychoactive drugs: anorectics C1 Other controlled substances: antidepressants, antiparkinsonians, anticonvulsants, antiepileptics, neuroleptics and anesthetics Special control prescription form, filled in two copies. A digital prescription can be used alternatively. C2 Retinoids: treatmeant of severe cystic acne White Prescription Notification form (the doctor request a printing press for it)
Contains a teratogenic warning and a sign. C3 Immunosuppressive drugs Prescription notification form, and a consent form regarding teratogenic risks, confirming understanding and agreeing to be the sole user of the drug. (form provided by a local public health organization to the doctor) C4 Antiretroviral drugs: management of HIV/AIDS - List revoked in September 2016. revoked C5 Anabolic steroids Special control prescription form, filled in two copies. A digital prescription can be used alternatively. D1 Drug precursors D2 Drug precursors E Controlled Plants and Fungi F Prohibited Substances Allowed only in authorized scientific research. F1 Prohibited narcotics F2 Prohibited psychotropics F3 Prohibited precursors F4 Other prohibited substances
Class A1
Acetylmethadol Alphacetylmethadol Alphameprodine Alphamethadol Alphaprodine Alfentanil Allylprodine Anileridine Bezitramide Benzethidine Benzylmorphine Benzoylmorphine () Betaacetylmethadol Betameprodine Betamethadol Betaprodine Buprenorphine Butorphanol Clonitazene Codoxime Concentrated opium poppy straw Dextromoramide Diampromide Diethylthiambutene Diphenoxylate Difenoxin Dihydromorphine Dimepheptanol Dimenoxadol Dimethylthiambutene Dioxaphetyl butyrate Dipipanone Drotebanol Ethylmethylthiambutene Etonitazene Etoxeridine Phenadoxone Phenampromide Phenazocine Phenomorphan Phenoperidine Fentanyl Furethidine Hydrocodone Hydromorphinol Hydromorphone Hydroxypethidine Methadone intermediate Moramide intermediate Pethidine intermediate A Norpethidine (Pethidine intermediate B) Pethidinic acid (Pethidine intermediate C) Isomethadone Levophenacylmorphan Levomethorphan Levomoramide Levorphanol Methadone Metazocine Methyldesorphine Methyldihydromorphine Metopon Myrophine Morpheridine Morphine Morinamide Nicomorphine Noracymethadol Norlevorphanol Normethadone Normorphine Norpipanone Codeine-N-oxide Morphine-N-oxide Opium Oripavine Oxycodone Oxymorphone Pethidine Piminodine Piritramide Proheptazine Properidine Racemethorphan Racemoramide Racemorphan Remifentanil Sufentanil Tapentadol Thebacon Thebaine Tilidine Trimeperidine Viminol
Class A2
Acetyldihydrocodeine Codeine Dextropropoxyphene Dihydrocodeine Ethylmorphine (Dionine) Pholcodine Nalbufina Nalorphine Nicocodine Nicodicodine Norcodeine Propiram Tramadol
Class A3
Amphetamine Cathine Chlorphentermine Dexamphetamine Dronabinol - Synthetic form with no other cannabinoid. Phenmetrazine Phencyclidine Phenethylline Levamphetamine Lisdexamfetamine Methylphenidate Methylsynephrine Thamphetamine Cannabis sativa derivates containing up to 30mg/mL THC and 30mg/mL CBD
Class B1
Allobarbital Alprazolam Amineptine Amobarbital Aprobarbital Armodafinil Barbexaclone Barbital Bromazepam Bromazolam Brotizolam Butabarbital Butalbital Camazepam Ketamine Ketazolam Cyclobarbital Clobazam Clonazepam Clonazolam Chlorazepam (CAS: , , ) Clorazepate Chlordiazepoxide Ethyl chloride Methylene chloride/dichloromethane Clotiazepam Cloxazolam Delorazepam Diazepam Diclazepam Esketamine Estazolam Eszopiclone Ethchlorvynol Ethylamphetamine (N-Ethylamphetamine) Ethinamate Etizolam Phenazepam Phenobarbital Flualprazolam Flubromazolam Fludiazepam Flunitrazepam Flunitrazolam Flurazepam GBL GHB Glutethimide Halazepam Haloxazolam Lefetamine Ethyl loflazepate Loprazolam Lorazepam Lormetazepam Medazepam Meprobamate Mesocarb Methylphenobarbital (prominal) Methyprylon Midazolam Modafinil Nimetazepam Nitrazepam Fencamfamin Nordazepam Oxazepam Oxazolam Pemoline Pentazocine Pentobarbital Perampanel Pinazepam Pipradrol Pyrovalerone Prazepam Prolintane Propylhexedrine Secbutabarbital Secobarbital Temazepam Tetrazepam Thiamylal Thiopental Triazolam Trichlorethylene Trihexyphenidyl Vinylbital Zaleplon Zolpidem Zopiclone Cannabis derivates containing up to 0,2% THC
Class B2
Aminorex Amfepramone Fenproporex Phendimetrazine Phentermine Mazindol Mefenorex Sibutramine
Class C1
Acepromazine Valproic acid Agomelatine Amantadine Amisulpride Amitriptyline Amoxapine Aripiprazole Asenapine Atomoxetine Azacyclonol Beclamide Benactyzine Benfluorex Benzydamine Benzoctamine Benzquinamide Biperiden Brexpiprazole Brivaracetam Bupropion Buspirone Butaperazine Butriptyline Cannabidiol - Synthetic form with no other cannabinoid. Captodiame Carbamazepine Caroxazone Celecoxib Cyclarbamate Cyclexedrine (CAS: , ) Cyclopentolate Cisapride Citalopram Clomacran Clomethiazole Clomipramine Chloralodol Chlorpromazine Chlorprothixene Clotiapine Clozapine Dapoxetine Desflurane Desipramine Desvenlafaxine Deutetrabenazine Dexetimide Dexmedetomidine Dibenzepine Dimetacrine Disopyramide Disulfiram Divalproex sodium Dixyrazine Donepezil Doxepin Droperidol Duloxetine Ectylurea (See Acylurea) (CAS: , ) Emylcamate Enflurane Entacapone Escitalopram Etomidate Etoricoxib Ethosuximide Levophacetoperane Phenprobamate Phenaglycodol Phenelzine Pheniprazine Phenytoin Fluphenazine Flumazenil Fluoxetine Flupentixol Fluvoxamine Gabapentin Galantamine Haloperidol Halothane Chloral hydrate Etodroxizine (Hydrochlorbenzethylamine) Hydroxydione Homofenazine Imiclopazine Imipramine Imipraminoxide Iproclozide Isocarboxazid Isoflurane Cenestil (Isopropyl-crotonyl-urea) (CAS: , ) Lacosamide Lamotrigine Leflunomide Levetiracetam Levomepromazine Levomilnacipran Lisuride Lithium Loperamide Loxapine Lumiracoxib Lurasidone Mavacamten Maprotiline Meclofenoxate Mephenoxalone Mefexamide Memantine Mepazine Mesoridazine Methylnaltrexone Methylpentynol Methysergide Metixene Methopromazine (CAS: , ) Methoxyflurane Mianserin Milnacipran Miltefosine Minaprine Mirtazapine Misoprostol - Hospital authorization only. Moclobemide Molnupiravir Moperone Naloxone Naltrexone Nefazodone Nialamide Isobutyl nitrite Isopentyl nitrite Isopropyl nitrite Nomifensine Nortriptyline Noxiptiline Olanzapine Opipramol Oxcarbazepine Oxybuprocaine Hydroxyphenamate Oxypertine Paliperidone Parecoxib Paroxetine Penfluridol Perphenazine Pergolide Pericyazine Pimozide Pipamperone Pipotiazine Pramipexole Pregabalin Primidone Prochlorperazine Promazine Propanidid Propiomazine Propofol Prothipendyl Protriptyline Proparacaine Quetiapine Ramelteon Rasagiline Reboxetine Ribavirin Rimonabant Risperidone Rivastigmine Rofecoxib Ropinirole Rotigotine Rufinamide Selegiline Sertraline Sevoflurane Sulpiride Sultopride Tacrine Teriflunomide Tetrabenazine Tetracaine Tiagabine Tianeptine Tiapride Thioproperazine Thioridazine Thiothixene Tolcapone Topiramate Tranylcypromine Trazodone Triclofos Trifluoperazine Trifluperidol Trimipramine Troglitazone Valdecoxib Sodium valproate Venlafaxine Veralipride Vigabatrin Vilazodone Vortioxetine Ziprasidone Zotepine Zuclopenthixol
Class C2
Acitretin Adapalene Bexarotene Isotretinoin Tretinoin
Class C3
Thalidomide Lenalidomide Pomalidomide
Class C4 List revoked in September 2016.
Class C5
Androstanolone Bolasterone Boldenone Chlorodehydromethyltestosterone Clostebol Dehydrochlormethyltestosterone Drostanolone Stanolone Stanozolol Ethylestrenol Fluoxymesterone Formebolone Gestrinone Mesterolone Methandienone Methandranone Methandriol Methenolone Methyltestosterone Mibolerone Nandrolone Norethandrolone Oxandrolone Oxymesterone Oxymetholone Prasterone (dehydroepiandrosterone - DHEA) Somapacitan Somatrogon Somatropin (Human Growth Hormone) Testosterone Trenbolone
Class D
Class D1
1-Boc-4-AP (CAS: , ) 1-phenyl-2-propanone 3,4-MDP-2-P ethyl glycidate (PMK ethyl glycidate) 3,4-MDP-2-P methyl glycidic acid (PMK glycidic acid) 3,4-MDP-2-P methyl glycidate (PMK glycidate) 3,4-Methylenedioxyphenyl-2-propanone 4-AP (N-Phenyl-4-piperidinamine) Anthranilic acid Phenylacetic acid Lysergic acid N-Acetylanthranilic acid Alpha-phenylacetoacetonitrile (APAAN) (CAS: , ) Alpha-phenylacetoacetamide (APAA) (CAS: , ) 4-ANPP Dihydroergometrine Dihydroergotamine Ephedrine Ergometrine Ergotamine Etafedrine Helional Isosafrole Methyl alpha-acetylphenylacetate (MAPA) - (CAS: , ) Norfentanyl Sassafras oil Long pepper oil Piperidine Piperonal Pseudoephedrine N-phenethyl-4-piperidinone (NPP) Safrole
Class D2
Acetone Hydrochloric acid Sulfuric acid Acetic anhydride Ethyl chloride Methylene Chloride Chloroform Ethyl Ether Methyl ethyl ketone Potassium permanganate Sodium sulphate Toluene Trichlorethylene
Class E
Cannabis sativa - except for registed products under allowed dosage mentioned in Class A3. Claviceps paspali (Ergot) Datura suaveolens Erythroxylum coca Lophophora williamsii (Coto Peyote) Mitragyna speciosa Papaver somniferum Prestonia amazonica Salvia divinorum
Class F
Class F1
2F-Viminol 2-Methyl-AP-237 (methyl analogue of bucinnazine) 3-Methylfentanyl 3-Methylthiofentanyl 4-Fluoroisobutyrfentanyl
Acetyl-alpha-methylfentanyl Acetylfentanyl Acetorphine Acryloylfentanyl AH-7921 Alpha-methylfentanyl Alpha-methylthiofentanyl Beta-hydroxy-3-methylfentanyl Beta-hydroxyfentanyl Brorphine Butyrfentanyl Butonitazene Carfentanil Ketobemidone Cyclopropylfentanyl Cocaine Crotonylfentanyl Desomorphine Dihydroetorphine Ecgonine Etazene (Etodesnitazene) Etonitazepyne Etorphine Furanylfentanyl Heroin Isotonitazene MDPV Metonitazene Methoxyacetylfentanyl
MPPP MT-45 N-Desethyletonitazene N-Pyrrolidino Metonitazene (, ) Ocfentanil Orthofluorofentanyl Parafluorobutyrfentanyl Parafluorofentanyl PEPAP Protonitazene Tetrahydrofuranylfentanyl Thiofentanyl U-47700 Valerylfentanyl
Class F2
LSD 1B-LSD 1cP-LSD 1P-LSD 2C-B 2C-C 2C-D 2C-E 2C-F 2C-I 2C-T-2 2C-T-7 2-MeO-Diphenidine 3-Fluorophenmetrazine