The canton of Saint-Loup-sur-Semouse is an administrative division of the Haute-Saône department, northeastern France. Its borders were modified at the French canton reorganisation which came into effect in March 2015. Its seat is in Saint-Loup-sur-Semouse.

It consists of the following communes:

Abelcourt Aillevillers-et-Lyaumont Ainvelle Briaucourt Conflans-sur-Lanterne Corbenay Éhuns Fleurey-lès-Saint-Loup Fontaine-lès-Luxeuil Fougerolles-Saint-Valbert (partly) Francalmont Hautevelle Magnoncourt Mailleroncourt-Charette Meurcourt Neurey-en-Vaux Sainte-Marie-en-Chaux Saint-Loup-sur-Semouse La Vaivre Velorcey La Villedieu-en-Fontenette Villers-lès-Luxeuil Visoncourt

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