Ouwehand is a Dutch surname. It translates to "old hand", but is thought to derive from Ouwehan ("Han Sr."), akin to Ouwejans ("John Sr.") and Jongejans ("John Jr."), or have been a misreading of Ouweland ("old land").Ouwehand at the Database of Surnames in The Netherlands. People with the surname include:

Cornelis Ouwehand, (1920–1996), Dutch anthropologist Cornelis Willem "Cor" Ouwehand (1892–1951),Ouwehand, Cornelis Willem (1892-1951) at "Biografieën van Nederlandse ondernemers" Dutch entrepreneur and founder of the Ouwehands Dierenpark, a zoo in Rhenen. Esther Ouwehand, (born 1976), Dutch politician Willem H. Ouwehand, (born 1953), Dutch hematologist

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