Large subunit ribosomal ribonucleic acid (LSU rRNA) is the largest of the two major RNA components of the ribosome. Associated with a number of ribosomal proteins, the LSU rRNA forms the large subunit of the ribosome. The LSU rRNA acts as a ribozyme, catalyzing peptide bond formation.
Characteristics + Characteristics of the LSU rRNA for exemplary species.TypeLSU rRNA sizeSpeciesLengthAccessionReference Bacterial (Prokaryotic) 23S Escherichia coli 2,905 nt NR_076322.1 Archaeal (Prokaryotic) 23S Halobacterium salinarum 2,906 nt NR_076247.1 Eukaryotic 5.8S & 28S Homo sapiens 157 + 5,025 nt NR_145821.1; M11167.1 Mitochondrial 16S Homo sapiens 1,559 nt NC_012920.1 Homo sapiens mitochondrion, complete genome. "Revised Cambridge Reference Sequence (rCRS): accession NC_012920", National Center for Biotechnology Information. Retrieved on 20 February 2017. Plastid 23S Arabidopsis thaliana 2,810 nt NC_000932.1
Use in phylogenetics LSU rRNA sequences are widely used for working out evolutionary relationships among organisms, since they are of ancient origin and are found in all known forms of life.
See also SSU rRNA: the small subunit ribosomal ribonucleic acid.
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