Manafov is a surname. Notable people with the surname include:
Asya Manafova (born 1941), Azerbaijani politician Fakhraddin Manafov (born 1955), Soviet Azerbaijani actor Marat Manafov, Azerbaijani businessman and missing person Ravil Manafov (born 1988), Kazakhstani water polo player Vladyslav Manafov (born 1993), Ukrainian tennis player