Ōkubo Tadayoshi may refer to:
Odawara Domain: Ōkubo Tadayoshi (I) () (1736–1769), the fifth daimyō of the Odawara Domain Ōkubo Tadayoshi (II) () (1857–1877), the 10th daimyō of the Odawara Domain
Karasuyama Domain:
Ōkubo Tadayoshi () (1769–1812), the fourth daimyō of the Ōkubo Karasuyama Domain Ōkubo Tadayoshi () (1848–1864), the seventh daimyō of the Ōkubo Karasuyama Domain