Amyx is a surname. Notable people with the surname include:
Darrell A. Amyx (1911–1997), American archaeologist Fleming Amyx, American politician Jay S. Amyx (1923–2014), American politician Mike Amyx, American politician Raleigh DeGeer Amyx (1938–2019), American FBI agent and Americana collector Cheryl Amyx (1962-), American IT Entrepreneur