Mazzucco is an Italian surname. Notable people with the surname include:
Alexandra Mazzucco (born 1993), German handball player Joe Mazzucco (1891–?), Italian racing driver Massimo Mazzucco (born 1954), Italian film director Melania Mazzucco (born 1966), Italian author Raphael Mazzucco, Canadian photographer Alberto Mazzucco (1911–1996), Italian ex-football player
See also Mazzucco Sanctuary, a religious sanctuary in Piedmont, Italy