Holguin or Holguín may refer to:
Places Holguín, a city in Cuba Holguín Province in Cuba
People Jeffrey Holguin (born 1978), an American sport shooter Brian Holguin, American comic book writer Jorge Holguín (1848–1928), a Colombian politician and military officer, and two time Acting President of Colombia Jose L. Holguin (1921–1994), a United States Air Force Colonel Juan Ignacio Larrea Holguín (1927–2006), archbishop of Guayaquil María Ángela Holguín (born in 1963), the Minister of Foreign Affairs of Colombia Pedro Álvarez Holguín (1490–1542), a Spanish nobleman, military and Conquistador of Perú
Sports Holguín (baseball), a Cuban team FC Holguín, a Cuban football team