Enciprazine (INN, BAN; enciprazine hydrochloride (USAN); developmental code names WY-48624, D-3112) is an anxiolytic and antipsychotic of the phenylpiperazine class which was never marketed. It shows high affinity for the α1-adrenergic receptor and 5-HT1A receptor, among other sites. The drug was initially anticipated to produce ortho-methoxyphenylpiperazine (oMeOPP), a serotonin receptor agonist with high affinity for the 5-HT1A receptor, as a significant active metabolite, but subsequent research found this not to be the case.
Synthesis
3,4,5-Trimethoxyphenol (antiarol, 1) is alkylated with epichlorohydrin (2) to give [(3,4,5-trimethoxyphenoxy)methyl]oxirane (3). Opening of the epoxide with o-anisyl-piperazine (4) completes the synthesis of enciprazine (5).
See also Acaprazine Batoprazine Eltoprazine Enpiprazole Fluprazine Lidanserin Ensaculin Mafoprazine BMY-14802 Azaperone Fluanisone
References
External links Enciprazine - AdisInsight