Mxolisi is a South African masculine given name. Notable people with the name include:
Mxolisi Dimaza, South African politician and trade unionist Mxolisi Dukwana (born 1964), South African politician Mxolisi Kaunda (born 1972), South African politician Mxolisi Lukhele (born 1991), Swazi football player Mxolisi Macuphu (born 1989), South African footballer Mxolisi Mgojo, South African businessman Mxolisi Mthethwa (born 1978), Swazi football midfielder Mxolisi Sizo Nkosi (born 1967), South African government official Mxolisi Nxasana, Director of Public Prosecutions in South Africa Mxolisi Siyonzana, South African politician
See also Mxolisa Sokatsha (1965–2022), South African politician