Marchione is an Italian surname. Notable people with the surname include:
Carlo Marchione (born 1964), Italian classical guitarist Frankie Grande Marchione (born 1983), American YouTuber and television host Kathy Marchione (born c. 1955), American politician Margherita Marchione (1922–2021), American Roman Catholic nun, writer, teacher and apologetic
See also Marchioni Marchione Guitars, an American guitar manufacturing company