Papagiannis (also spelled Pappagianis) () is a Greek surname. It can refer to:
George S. Pappagianis (1924–2017), American politician, Attorney General of New Hampshire Georgios Papagiannis (born 1997), Greek basketball player Ithaka Darin Pappas (Pappagianis) (born 1966) Californian multidisciplinary artist Manthos Papagiannis, 16th century Greek noble and revolutionary Theodoros Papagiannis (born 1942), Greek sculptor