Mdluli is an African surname that may refer to John Mdluli (born 1972), Swaziland football player Labotsibeni Mdluli (c.1859–1925), Queen Mother and Queen Regent of Swaziland Mlondi Mveli Mdluli (born 1998), South African politician Mlungisi Mdluli (born 1980), South African football midfielder Philippa Mdluli (1935/1936–1983), Swaziland businesswoman, child killer and cannibal Richard Mdluli (born 1958), head of Police Crime Intelligence in South Africa Siyabonga Mdluli (born 1986), Swaziland football player K.O (rapper) (born Ntokozo Mdluli), South African rapper Kaunda Mdluli (born 1990), Swaziland businessman Pat Mdluli (born 1989) a South African humanitarian Ayanda Mdluli (born 1985), a South African journalist and newspaper editor