Cluzel is a French surname. It derives from the Occitan clusèl, meaning 'small enclosure', 'small enclosed space'. Notable people with the surname include:
Jean Cluzel (1923–2020), French politician Jean-Paul Cluzel (born 1947), French politician Jules Cluzel (born 1988), French motorcycle racer Sophie Cluzel (born 1961), French politician
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