Mpofu is a surname found in Southern Africa, mainly in Zimbabwe and South Africa. Notable people with this surname include:
Christopher Mpofu (born 1985), Zimbabwean cricketer Dali Mpofu (born 1962), South African lawyer and politician Elizabeth Mpofu (born 1959), Zimbabwean farmer and activist Mpumi Mpofu, South African Secretary of Defence Nkosana Mpofu (born 1988), Zimbabwean cricketer Obert Mpofu, Zimbabwean politician Sizwe Mpofu-Walsh (born 1989), South African author, musician, activist and son of Dali Mpofu Tafadzwa Mpofu (born 1985), Zimbabwean cricketer
Quinton Qhawe Mpofu (born 2007), South African scholar Dliwe Mpofu (born 1979), Zimbabwean Police Officer