Mazibuko is a South African surname that may refer to:
Abednego Mazibuko, South African singer Albert Mazibuko, South African singer, brother of Abednego Clement Mazibuko (born 1977), South African football midfielder Fusi Mazibuko (born 1980), South African basketball player Gcina Mazibuko (born 1983), Swaziland football striker Goodman Mazibuko (born 1975), South African football midfielder Lindiwe Mazibuko (born 1980), South African politician and musician Seth Mazibuko, South African anti-apartheid activists Vusumuzi Mazibuko (born 1984), South African cricketer