Calcaño is a surname. Notable people with the surname include:
Héctor Calcaño (1894–1969), Argentine actor María Calcaño (1906–1956), Venezuelan poet Mary Calcaño (1906–1992), first Venezuelan woman to be granted a pilot's licence Graciela Rincón Calcaño (1904–1987), Venezuelan writer and poet Rafael Devers Calcaño (born 1996), Dominican baseball player