Sereni is an Italian surname. Notable people with the surname include:
Clara Sereni (1946–2018), Italian writer Emilio Sereni (1907–1977), Italian politician Enzo Sereni (1905–1944), Italian Zionist Marina Sereni (born 1960), Italian politician Mario Sereni (1928–2015), Italian opera singer Matteo Sereni (born 1975), Italian footballer Vittorio Sereni (1913–1983), Italian poet and writer