Lotito is a surname. Notable people with the surname include:
Claudio Lotito (born 1957), Italian entrepreneur Frank Lotito (born 1971), Australian actor, comedian, film director, and film producer Lawrence Lotito (1921–2004), American business owner, meteorologist, and Air Force officer Michel Lotito (1950–2007), French entertainer Cataldo Lotito Quercia (1938–2003), Italian, Venezuelan businessman