Mantegazza is an Italian surname. Notable people with the surname include:
Cristoforo Mantegazza (c.1430–1482), Italian sculptor Giacomo Mantegazza (1851–1920), Italian painter Laura Solera Mantegazza (1813–1873), Italian patriot, philanthropist and fundraiser Paolo Mantegazza (1831–1910), Italian neurologist, physiologist, and anthropologist Sergio Mantegazza (1927–2024), Swiss businessman, chairman and owner of Globus Virgilio Mantegazza (1889–1928), Italian fencer Walter Mantegazza (1952–2006), Uruguayan footballer