Isaković () is a Bosniak and Serb patronymic surname derived from a masculine given name Isak (Isaac). It may refer to:
Aladin Isaković (born 1985), Bosnian footballer Alija Isaković (1932–1997), Bosnian writer Antonije Isaković (1923–2002), writer Boris Isaković (born 1966), actor Branko Isaković (born 1958), musician Mile Isaković (born 1958), handball player Mirjana Isaković (born 1936), artist Sara Isaković (1988), swimmer Vuk Isaković (1696–1759), military commander