Esterhuizen is a surname. Notable people with the surname include:
André Esterhuizen (born 1994), South African rugby union player Bernard Esterhuizen (born 1992), South African track cyclist Connor Esterhuizen (born 2021), South African cricketer Quintin Esterhuizen (born 1994), Namibian rugby union player Willie Esterhuizen, South African director, producer, writer and actor (born 1954)