Sesam, SESAM or SeSaM may refer to:
SESAM (database), a relational database developed by Fujitsu Siemens SESAM (FEM), a structural analysis software Sesam (search engine), a Scandinavian internet search engine SeSaM-Biotech GmbH, a biotechnology company focusing on protein engineering Semiconductor saturable-absorber mirror, a component used in some lasers Sequence saturation mutagenesis (SeSaM), a molecular biology method for diversity creation by random mutagenesis
See also Sesame (disambiguation) Various wild and cultivated plants in the genus Sesamum