Aesc may refer to:
Æsc, Old English for the ash tree; see Fraxinus Æsc (rune) (ᚫ), a rune of the Anglo-Saxon fuþorc and a continuation of the Elder Fuþark ansuz (ᚨ) Æ, a letter of the Old English alphabet Oisc of Kent, sometimes called Aesc, a legendary early leader of the Anglo-Saxon kingdom of Kent Automotive Energy Supply Corporation (AESC), manufacturer of lithium based batteries for electric vehicles Aesc., abbreviation for the tree genus Aesculus