The 1921 San Jose State Spartans football team represented State Teachers College at San JoseSan Jose State University was known as State Teachers College at San Jose from 1921 to 1934. during the 1921 college football season.

This was the first season of intercollegiate football for San Jose State since 1900. The 1921 team was led by head coach David Wooster, and they played home games at Spartan Field in San Jose, California. The team finished the season with a record of one win and five losses (1–5). The Spartans were outscored by their opponents 35–141 for the season. In 1922, they became a charter member of the California Coast Conference (CCC).

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