Di Cecco () is an Italian surname, derived from the given name Cecco. Notable people with the surname include:

Alberico Di Cecco (born 1974), Italian long-distance and marathon runner Domenico Di Cecco (born 1983), Italian footballer Domenico di Cecco, 15th-century Italian painter Felice Di Cecco (born 1994), Italian footballer Francescuccio di Cecco Ghissi (), Italian painter Giovanni di Cecco, 14th-century Italian architect and sculptor Gregorio di Cecco (–c. 1424), Italian painter

See also De Cecco (surname)