Esco may refer to the following people:
Given name Esco Sarkkinen (1918–1998), American football player and coach Esco Haynes, American professional baseball player Esco Niblo Bowen (born 1893 – died 1959), American lawyer, judge and politician Sigmund Esco Jackson (born 1951), American singer and musician William Esco Moerner (born 1953), American physical chemist and chemical physicist awarded Nobel Prize in Chemistry in 2014
Surname Lina Esco (born 1985), American actress
Nickname DJ Esco (born 1990), American DJ from Georgia Nas (born 1973), nicknamed Esco, American rapper