Mphande is a surname. Notable people with the surname include:
David Mphande (1938–2018), Malawian politician and educator Gift Mphande (born 2003), Zambian footballer Lyton Mphande (born 1963), Malawian boxer
See also
Mpanda (disambiguation) Mpande (1798–1872), monarch of the Zulu Kingdom Joseph Mpande (born 1994), Ugandan footballer