Alpern is a surname. Notable people with the name include:
Anne X. Alpern (1903–1981), American jurist and politician Anita Alpern (1920–2006), American government administrator Evelyn Alpern (1903–1977), American psychiatrist Mathew Alpern (1920–1996), American physiologist Merry Alpern (born 1955), American photographer Ruth Alpern Madoff (born 1941), American wife of Bernie Madoff Sara Alpern (born 1942), American historian Steve Alpern, American mathematician