Laybourne is a surname. Notable people with the surname include:

Geraldine Laybourne (born 1947), American entrepreneur Jack Laybourne (born 1927), English footballer Kit Laybourne, American TV producer and educator Rachel Laybourne (born 1982), British volleyball player Roxie Collie Laybourne (1910–2003), American ornithologist from North Carolina Louis Laybourne Smith (1880–1965), architect and educator from South Australia

See also Woods, Bagot, Laybourne Smith & Irwin, global architectural and consulting practice founded in Australia Claybourne Larry Bourne Laybourn