Lyr or LYR may refer to:
Mythology Llŷr, a Welsh figure Lir, an Irish sea god Leir of Britain, a pseudohistorical king
Science Lyra (Lyr), a northern constellation Light-year (ly or lyr), an astronomical unit of distance LYR protein, a protein containing a leucine–tyrosine–arginine (LYR) tripeptide, should not be confused with LYRM protein
Transport Lancashire and Yorkshire Railway, England (1847–1923) Svalbard Airport, Longyear, Norway (IATA code:LYR) Layar LRT station, Singapore (LRT code:LYR)
Other uses LYR (band), led by Simon Armitage
See also Llŷr (given name) Lyre, a musical instrument