Desvignes is a French surname. Notable people with the surname include:
Lucette Desvignes (1926–2024), French writer Margot Desvignes Peter Hubert Desvignes Pierre Desvignes (1764–1827), French composer Thomas Desvignes (1812–1868), English entomologist Fabrice Desvignes (born 1972), French chef, winner of the 2007 Bocuse d'Or See also Sidney Desvigne