Christofi is a Greek surname, commonly found in Cyprus. Notable people with the surname include:
Alex Christofi, British Cypriot novelist Alkiviadis Christofi (born 1992), Cypriot footballer Demetris Christofi (born 1988), Cypriot footballer Demetris Christofi (born 1994), Cypriot footballer Eleni Christofi (born 1998), Greek tennis player Styllou Christofi (1900–1954), Greek Cypriot convicted of murder