Phosphoglycerate mutase 1 is an enzyme that in humans is encoded by the PGAM1 gene. This enzyme functions as a phosphoglycerate mutase, and catalyzes a step of glycolysis (breaking down of glucose). This protein is notably expressed in the liver and brain, compared to phosphoglycerate mutase 2 which is mainly expressed in the muscles and heart.
Function As a phosphoglycerate mutase (5.4.2.11), this enzyme is able to catalyze the following reaction (in both directions): (2R)-2-phosphoglycerate (2R)-3-phosphoglycerate
Despite its name, it is also able to function as a Bisphosphoglycerate mutase (EC 5.4.2.4) like its paralog BPGM: (2R)-3-phospho-glyceroyl phosphate (2R)-2,3-bisphosphoglycerate + H+
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