Brisby is a surname. Notable people with the surname include:
Liliana Brisby (1923–1998), Bulgarian-born British broadcaster, writer, editor, and concert pianist Vincent Brisby (born 1971), American football player Emanual Brisby (born 1988), Mailman
Fictional characters Mrs. Brisby (originally Mrs. Frisby in Robert C. O'Brien's 1971 children's novel Mrs. Frisby and the Rats of NIMH), the main protagonist in 1982 animated film adaptation The Secret of NIMH
See also Risby (disambiguation)