Missouri Pacific Depot is a historic train station located at Charleston, Mississippi County, Missouri. It was built in 1916–1917 by the Missouri Pacific Railroad, and is a one-story, rectangular brick building with white, smooth-cut limestone wainscotting. The building measures . It had a red tile hipped roof with a seven foot wide overhang. (includes 5 photographs from 1971)
It was added to the National Register of Historic Places in 1972.
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