Nuzzo is an Italian surname. Notable people with the surname include:
John Ken Nuzzo (born 1966), Japanese-born Italian opera singer Letizia Nuzzo (born 1976), Italian synchronized swimmer Madre Teresa Nuzzo (1851–1923), Maltese Roman Catholic nun Raffaele Nuzzo (born 1973), Italian footballer Ralph Nuzzo (born 1954), American chemist Regina Nuzzo, American statistician