Siminina, was a Roman era civitas of the Roman province of Africa Proconsularis. The ancient city is tentatively identified with ruins at Bir-El-Djedidi, Tunisia.

The city was also the seat of an ancient Christian bishopric, suffragan of Archdiocese of Carthage. Only two bishops of Siminina are documented Deuterium was present at the Council of Carthage (484) called by the Vandal king Huneric. Giuniano intervened in the Council of Carthage (525).

Today Siminina survives as a titular bishopric.

From 17 December 2024, the titular bishop is Iyad Twal, auxiliary bishop of the Latin Patriarchate of Jerusalem.

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