Giacomini is an Italian surname, derived from the diminutive of the masculine Italian personal name Giacomo (James). Notable people with the surname include:
Andrea Giacomini (born 1987), Italian footballer Audrey Giacomini (born 1986), French actress and model Breno Giacomini (born 1985), American football offensive tackle Carlo Giacomini (1840–1898), Italian anatomist and neuroscientist Diogo Giacomini (born 1979), Brazilian football manager Gianni Giacomini (born 1958), retired Italian cyclist Giuseppe Giacomini (1940–2021), Italian dramatic tenor Kathleen Giacomini, American bioengineer Massimo Giacomini (born 1939), retired Italian football player and football manager