Mark Twain Hotel is a historic hotel building located at Hannibal, Marion County, Missouri. It was designed by Barnett, Haynes & Barnett and built in 1905. It is a four-story, Renaissance Revival style steel-frame structure with a granite foundation and beige pressed-brick exterior. The annex was built in 1918. It features semicircular arches over the main door and adjacent windows. and Site map

It was then added to the National Register of Historic Places in 1986.

It was converted to senior apartments in 2006.https://www.hmdb.org/m.asp?m=150217

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