Biagini is an Italian surname. Notable people with the surname include:
Eugenio Biagini (born 1958), Italian historian Francesca Biagini (born 1973), Italian-German mathematician Greg Biagini (1952–2003), American player, coach and manager in minor league baseball Isabella Biagini (1943–2018), Italian actress and showgirl Joe Biagini (born 1990), American professional baseball pitcher Leonardo Biagini (born 1977), Argentine retired footballer Luca Biagini (born 1949), Italian actor and voice actor