Pieroni is an Italian surname. Notable people with the surname include:
Alessandro Pieroni (1550–1607), Italian architect and painter Andrea Pieroni (ethnobotanist) (born 1967), Italo-German ethnobiologist Ania Pieroni (born 1957), former Italian actress Blake Pieroni (born 1995), American competition swimmer Fanny Pieroni-Davenport, Italian painter Giovanni de Galliano Pieroni (1586–1654), Italian military engineer specializing in erecting fortifications Luigi Pieroni (born 1980), former Belgian football striker Margaret Pieroni, Australian botanical artist and botanist