St. John's Mercy Hospital Building is a historic hospital building located at Springfield, Greene County, Missouri. The building was constructed in four stages: The original section was built in 1906 (demolished about 1970); a separate convent was constructed in 1914; a four-story Jacobethan addition was added in 1922; and in 1944 a four-story unit and gymnasium were constructed. The brick and limestone building features Tudor arch and segmental arch openings. (includes 12 photographs from 2003)

It was listed on the National Register of Historic Places in 2003.

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