Caldwell Creek is a stream in Wayne County in the U.S. state of Missouri. It is a tributary of the St. Francis River.

The stream headwaters arise just south of Missouri Route HH and east of US Route 67 at and it flows to the southeast. The confluence with the St. Francis is within the waters of Lake Wappapello south of the Holiday Landing campground at . The confluence is about six miles south of Greenville.Greenville SW, Missouri, 7.5 Minute Topographic Quadrangle, USGS, 1966 (1976 rev.)

Caldwell Creek has the name of James Caldwell, a pioneer citizen.

See also List of rivers of Missouri

References