Skunk Creek is a stream in Warren County in the U.S. state of Missouri. It is a tributary of Peruque Creek.
The stream headwaters arise at at an elevation of approximately 800 feet.Wright City, MO, 7.5 Minute Topographic Quadrangle, USGS, 1972 (1986 rev.) The stream flows generally north passing under Missouri Route M and on for about 2.5 miles to its confluence with Peruque Creek approximately one-half mile southeast of Wright City and I-70 at at an elevation of 682 feet.
A variant name was "Skunk Branch". The creek was so named on account of skunks in the area.
See also List of rivers of Missouri
References