Oxysoma is a genus of South American anyphaenid sac spiders first described by H. Nicolet in 1849.

Species it contains eight species: Oxysoma chiloensis (Ramírez, 2003) – Chile, Argentina Oxysoma itambezinho Ramírez, 2003 – Brazil Oxysoma kuni Aisen & Ramírez, 2015 – Chile Oxysoma longiventre (Nicolet, 1849) – Chile, Argentina Oxysoma losruiles Aisen & Ramírez, 2015 – Chile Oxysoma macrocuspis Aisen & Ramírez, 2015 – Chile Oxysoma punctatum Nicolet, 1849 – Chile, Argentina Oxysoma saccatum (Tullgren, 1902) – Chile, Argentina

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