Femme Osage is an unincorporated community in southwest St. Charles County, in the U.S. state of Missouri. The community is on Missouri Route T along the bank of the Femme Osage Creek.Missouri Atlas & Gazetteer, DeLorme, 1998, First edition, p. 40,
History A post office Femme Osage was in operation from 1816 until 1933. The community takes its name from nearby Femme Osage Creek.
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